LeHavreV1, France, Analysis, bibRecord, 001599

Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects

Identifieur interne : 001599 ( France/Analysis ); précédent : 001598; suivant : 001600

Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects

Auteurs : C. Lacroix [France] ; T. Phan Hoang [France] ; J. Nouveau [France] ; C. Guyonnaud [France] ; G. Laine [France] ; H. Duwoos [France] ; O. Lafont [France]

Source :

European Journal of Clinical Pharmacology [ 0031-6970 ] ; 1989-07-01.

RBID : ISTEX:6581BE6C49CC8E0001F52B4D5780AC33E652BEDB

English descriptors

KwdEn :
- Chromatography, High Pressure Liquid, Half-Life, Humans, Male, Pyrazinamide (analogs & derivatives), Pyrazinamide (pharmacokinetics).
MESH :
- chemical , analogs & derivatives : Pyrazinamide.
- chemical , pharmacokinetics : Pyrazinamide.
- Chromatography, High Pressure Liquid, Half-Life, Humans, Male.

Abstract

Summary: The plasma and urine pharmacokinetic parameters of pyrazinamide and of its metabolites (pyrazinoic acid, 5-hydroxy-pyrazinamide, 5-hydroxy-pyrazinoic acid and pyrazinuric acid) have been studied after a single oral dose of pyrazinamide 27 mg · kg−1 in 9 healthy subjects. Pyrazinamide was rapidly absorbed (tmax ≤1 h) and showed a short distribution phase followed by an elimination phase of t1/2β=9.6 h. The close similarity of the apparent elimination rates of the metabolites led to a second trial of a single oral dose of pyrazinoic acid to evaluate the formation and elimination stages. The limiting factor was found to be the activity of a microsomal deamidase (pyrazinoic acid formation from pyrazinamide and 5-hydroxy-pyrazinoic acid formation from 5-hydroxy-pyrazinamide). In contrast, oxidation by xanthine oxidase occurred very rapidly (5-hydroxy-pyrazinamide formation and pyrazinoic acid catabolism to 5-hydroxy-pyrazinoic acid).

Url:

https://api.istex.fr/document/6581BE6C49CC8E0001F52B4D5780AC33E652BEDB/fulltext/pdf

DOI: 10.1007/BF00558302

Affiliations:

France
Le Havre, Rouen

Links to Exploration step

ISTEX:6581BE6C49CC8E0001F52B4D5780AC33E652BEDB

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects</title>
<author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C." last="Lacroix">C. Lacroix</name>
</author>
<author><name sortKey="Phan Hoang, T" sort="Phan Hoang, T" uniqKey="Phan Hoang T" first="T." last="Phan Hoang">T. Phan Hoang</name>
</author>
<author><name sortKey="Nouveau, J" sort="Nouveau, J" uniqKey="Nouveau J" first="J." last="Nouveau">J. Nouveau</name>
</author>
<author><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C." last="Guyonnaud">C. Guyonnaud</name>
</author>
<author><name sortKey="Laine, G" sort="Laine, G" uniqKey="Laine G" first="G." last="Laine">G. Laine</name>
</author>
<author><name sortKey="Duwoos, H" sort="Duwoos, H" uniqKey="Duwoos H" first="H." last="Duwoos">H. Duwoos</name>
</author>
<author><name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O." last="Lafont">O. Lafont</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:6581BE6C49CC8E0001F52B4D5780AC33E652BEDB</idno>
<date when="1989" year="1989">1989</date>
<idno type="doi">10.1007/BF00558302</idno>
<idno type="url">https://api.istex.fr/document/6581BE6C49CC8E0001F52B4D5780AC33E652BEDB/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000266</idno>
<idno type="wicri:Area/Istex/Curation">000266</idno>
<idno type="wicri:Area/Istex/Checkpoint">001285</idno>
<idno type="wicri:doubleKey">0031-6970:1989:Lacroix C:pharmacokinetics:of:pyrazinamide</idno>
<idno type="wicri:Area/Main/Merge">002715</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:2737233</idno>
<idno type="wicri:Area/PubMed/Corpus">000448</idno>
<idno type="wicri:Area/PubMed/Curation">000448</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000448</idno>
<idno type="wicri:Area/Ncbi/Merge">000553</idno>
<idno type="wicri:Area/Ncbi/Curation">000553</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000553</idno>
<idno type="wicri:doubleKey">0031-6970:1989:Lacroix C:pharmacokinetics:of:pyrazinamide</idno>
<idno type="wicri:Area/Main/Merge">002665</idno>
<idno type="wicri:Area/Main/Curation">002642</idno>
<idno type="wicri:Area/Main/Exploration">002642</idno>
<idno type="wicri:Area/France/Extraction">001599</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects</title>
<author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C." last="Lacroix">C. Lacroix</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Departments of Pharmacokinetics and Pneumology, Centre Hospitalier Général, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Phan Hoang, T" sort="Phan Hoang, T" uniqKey="Phan Hoang T" first="T." last="Phan Hoang">T. Phan Hoang</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Departments of Pharmacokinetics and Pneumology, Centre Hospitalier Général, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nouveau, J" sort="Nouveau, J" uniqKey="Nouveau J" first="J." last="Nouveau">J. Nouveau</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Departments of Pharmacokinetics and Pneumology, Centre Hospitalier Général, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C." last="Guyonnaud">C. Guyonnaud</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Departments of Pharmacokinetics and Pneumology, Centre Hospitalier Général, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laine, G" sort="Laine, G" uniqKey="Laine G" first="G." last="Laine">G. Laine</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Departments of Pharmacokinetics and Pneumology, Centre Hospitalier Général, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duwoos, H" sort="Duwoos, H" uniqKey="Duwoos H" first="H." last="Duwoos">H. Duwoos</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Departments of Pharmacokinetics and Pneumology, Centre Hospitalier Général, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O." last="Lafont">O. Lafont</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Organic Chemistry, Faculté de Médecine et de Pharmacie, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">European Journal of Clinical Pharmacology</title>
<title level="j" type="abbrev">Eur J Clin Pharmacol</title>
<idno type="ISSN">0031-6970</idno>
<idno type="eISSN">1432-1041</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1989-07-01">1989-07-01</date>
<biblScope unit="volume">36</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="395">395</biblScope>
<biblScope unit="page" to="400">400</biblScope>
</imprint>
<idno type="ISSN">0031-6970</idno>
</series>
<idno type="istex">6581BE6C49CC8E0001F52B4D5780AC33E652BEDB</idno>
<idno type="DOI">10.1007/BF00558302</idno>
<idno type="ArticleID">BF00558302</idno>
<idno type="ArticleID">Art13</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0031-6970</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromatography, High Pressure Liquid</term>
<term>Half-Life</term>
<term>Humans</term>
<term>Male</term>
<term>Pyrazinamide (analogs & derivatives)</term>
<term>Pyrazinamide (pharmacokinetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Pyrazinamide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Pyrazinamide</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Chromatography, High Pressure Liquid</term>
<term>Half-Life</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Summary: The plasma and urine pharmacokinetic parameters of pyrazinamide and of its metabolites (pyrazinoic acid, 5-hydroxy-pyrazinamide, 5-hydroxy-pyrazinoic acid and pyrazinuric acid) have been studied after a single oral dose of pyrazinamide 27 mg · kg−1 in 9 healthy subjects. Pyrazinamide was rapidly absorbed (tmax ≤1 h) and showed a short distribution phase followed by an elimination phase of t1/2β=9.6 h. The close similarity of the apparent elimination rates of the metabolites led to a second trial of a single oral dose of pyrazinoic acid to evaluate the formation and elimination stages. The limiting factor was found to be the activity of a microsomal deamidase (pyrazinoic acid formation from pyrazinamide and 5-hydroxy-pyrazinoic acid formation from 5-hydroxy-pyrazinamide). In contrast, oxidation by xanthine oxidase occurred very rapidly (5-hydroxy-pyrazinamide formation and pyrazinoic acid catabolism to 5-hydroxy-pyrazinoic acid).</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<settlement><li>Le Havre</li>
<li>Rouen</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C." last="Lacroix">C. Lacroix</name>
</noRegion>
<name sortKey="Duwoos, H" sort="Duwoos, H" uniqKey="Duwoos H" first="H." last="Duwoos">H. Duwoos</name>
<name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C." last="Guyonnaud">C. Guyonnaud</name>
<name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O." last="Lafont">O. Lafont</name>
<name sortKey="Laine, G" sort="Laine, G" uniqKey="Laine G" first="G." last="Laine">G. Laine</name>
<name sortKey="Nouveau, J" sort="Nouveau, J" uniqKey="Nouveau J" first="J." last="Nouveau">J. Nouveau</name>
<name sortKey="Phan Hoang, T" sort="Phan Hoang, T" uniqKey="Phan Hoang T" first="T." last="Phan Hoang">T. Phan Hoang</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001599 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 001599 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/France
   |area=    LeHavreV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     ISTEX:6581BE6C49CC8E0001F52B4D5780AC33E652BEDB
   |texte=   Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects
}}

This area was generated with Dilib version V0.6.25.
Data generation: Sat Dec 3 14:37:02 2016. Site generation: Tue Mar 5 08:25:07 2024

Serveur d'exploration sur la visibilité du Havre

Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects

Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur la visibilité du Havre
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.